Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination
نویسندگان
چکیده
منابع مشابه
Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish
Antisense oligonucleotides (ASOs) are synthetic, single-strand RNA-DNA hybrids that induce catalytic degradation of complementary cellular RNAs via RNase H. ASOs are widely used as gene knockdown reagents in tissue culture and in Xenopus and mouse model systems. To test their effectiveness in zebrafish, we targeted 20 developmental genes and compared the morphological changes with mutant and mo...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2020
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2019.12.011